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Studies: mutated gene increases risk of miscarriage

Studies: mutated gene increases risk of miscarriage


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Women with a mutated FOXD1 gene are more likely to experience recurrent spontaneous abortions
Miscarriage is an event that scares pregnant women. Researchers have now found that certain women have an increased risk of miscarriage. These women have a mutated gene in their body that makes miscarriage more likely.

An international team of scientists found in an investigation that the bodies of some women contain a mutated gene, which leads to miscarriages. This mutated gene is called FOXD1. The doctors published the results of their study in the journal "Open Biology".

Mutated gene leads to miscarriages within the first five weeks
Certainly all women are very afraid of miscarriage. Doctors found that certain women were more likely to miscarry within the first five weeks of their pregnancy. A mutated gene that is found in the body of some women seems to be to blame.

Findings could enable more effective diagnoses
In its normal state, the so-called FOXD1 gene actually appears to have some kind of protection quality, the experts say. However, if the gene mutates, it increases the likelihood of miscarriage in mothers-to-be. Doctors now hope that the current finding enables a more effective diagnosis of possible miscarriages. In this way, better treatment of the women concerned can be achieved.

Study analyzes data from 556 women with RSA
The research team analyzed the data of 556 women who had previously been affected by so-called recurrent spontaneous abortion (RSA). This expression defines if a woman suffers three or more miscarriages in a row within the first five weeks of pregnancy, the authors explain. It is believed that approximately one in a hundred pregnancies is related to such a condition. 271 women who did not suffer from such problems served as a control group.

FOXD1 gene could normally have a protective effect
We found that women with a FOXD1 mutation have a statistically increased risk of developing RSA, the authors explain. The doctors also found the gene in women from the control group. For this reason, the experts suspect that the gene could even have a protective effect in the normal state.

Gene was first found in an animal experiment
The gene was first found in laboratory mice. There was a high level of embryonic absorption in these animals. With embryonic absorption, one fetus of twins dies during pregnancy and is then reabsorbed by the other twin, the doctors explain. FOXD1 is not the first gene that has been involved in repeated miscarriages. So far, however, so-called functional evidence of participation has been rare, the scientists explain.

Nausea and vomiting reduce the likelihood of miscarriage
Another study last month found that if pregnant women experience morning sickness, this reduces the likelihood of miscarriage. Morning feelings of nausea and vomiting could be linked to a 75 percent reduction in miscarriage, the doctors add. (as)

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