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Dementia research: can aspirin protect against Alzheimer's disease?


How aspirin strengthens brain waste management

American researchers recently published a study that found a link between aspirin and a reduced risk of Alzheimer's disease. In addition, the popular pain reliever should ensure that the disease process in patients slows down significantly. According to the scientists, a low dose of aspirin can ensure that the harmful deposits (plaques) in the brain are reduced. These plaques are considered to be one of the causes of Alzheimer's dementia.

The research team at the American "Rush University Medical Center" found in their research that aspirin can reduce harmful plaque formation in the brain, which should protect the memory and reduce the risk of developing Alzheimer's disease. The results were recently published in the "Journal of Neuroscience".

Aspirin - one of the most commonly used drugs

"The results of our study identify a potential new role for one of the most widely used, widely traded drugs in the world," Kalipada Pahan, lead author of the study and head of research, said in a press release on the study results.

Alzheimer's is an increasing problem in America too

Alzheimer's disease is a deadly form of dementia. According to the experts, one in ten Americans aged 65 years or older is affected by this disease. The increasing number of illnesses are opposed to only a few treatment options and effective medications. All current therapies can provide limited symptom relief.

Causes still unknown

The exact causes of Alzheimer's are still considered insufficiently understood. One of the most promising strategies for slowing Alzheimer's disease is the better elimination of brain waste, the so-called amyloid plaques.

How do the amyloid plaques damage the brain?

The protein amyloid-beta forms clumps that are deposited in the brain and damage the connections between nerve cells. According to the current state of knowledge, the poor disposal of the toxic protein amyloid beta in the brain is considered a leading mechanism in the development of dementia and memory loss. These proteins then form the plaques, i.e. the clogging deposits.

Aspirin helps remove plaque

Building on previous studies on the subject, Pahan and his colleagues have shown in animal experiments on mice that aspirin reduces the number of amyloid plaques in the brain. "Understanding how plaques are removed is important for developing effective medications that stop the progression of Alzheimer's disease," says Pahan.

Mice with Alzheimer's

Genetically modified mice with increased amounts of the amyloid plaque had to be used as the basis for research. The researchers administered aspirin to the mice for a month, and then examined the amount of plaque in the parts of the brain that are most affected by Alzheimer's disease.

Aspirin strengthens the body's clean-up proteins

The scientists found that the aspirin drugs boosted the TFEB protein. This protein is considered to be the main regulator of waste disposal in the brain and its amplification led to a reduction in amyloid plaques in the mouse brains. "This study adds another potential benefit to the already established uses of aspirin for pain relief and heart disease treatment," said Pahan.

Further research needed

The study leader emphasizes the importance of further research in this area: "The results of our study have great potential effects on the therapeutic use of aspirin in Alzeimer and other dementias," said the expert. (vb)

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